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But there aren’t many studies on the long-term effects of TRT (for example, over decades). If you don’t have these health concerns, TRT is generally safe. This is why healthcare providers do extensive evaluations and tests before approving the use of TRT. Certain existing health conditions make TRT unsafe, like prostate cancer, breast cancer and heart failure. TRT can decrease sperm count and cause fertility issues. If you stop TRT, you’ll return to your normal level of testosterone. But it’s important to remember that TRT comes with potential risks and side effects. Before starting TRT, your healthcare provider will make sure low testosterone is an accurate diagnosis. Certain existing health conditions make it unsafe, like prostate cancer and heart failure. Or you may have a genetic condition that causes issues. For example, chemotherapy or radiation therapy can damage one of these organs. Together, you and your healthcare provider will decide if TRT is right for you. Testosterone replacement therapy (TRT) is an option for men who have low testosterone levels due to male hypogonadism. Advertising on our site helps support our mission. Although this new information is somewhat reassuring, men and their doctors should still weigh these issues before committing to long term testosterone therapy. For men who clearly have testosterone deficiency, there is no apparent increased risk of heart attack or stroke or greater chance of developing a new prostate cancer from testosterone replacement therapy. Recent clinical trials, which provide more accurate information compared to observational studies, have provided some comfort around both the heart and prostate cancer risks. Older observational studies suggested that long term testosterone use could increase their risk of cardiovascular disease. A relatively small number of men experience immediate side effects of testosterone supplementation, such as acne, disturbed breathing while sleeping (worsening sleep apnea), breast swelling or tenderness, or swelling in the ankles. If a man's testosterone is below the normal range, it's best to repeat it once more to be sure before starting testosterone therapy - often staying on it indefinitely. General fatigue and malaise has so many other causes, and when most men get a blood test, the result is a normal testosterone level. Just being tired isn't enough to seek testosterone replacement therapy. Marketers urge men to talk to their doctors if they have certain "possible signs" that mean they could need low-T treatment. Share this page to Facebook Share this page to X Share this page via Email Copy this page to clipboard That’s why regular monitoring and collaboration with your healthcare provider are essential to ensure your treatment plan is optimizing your health without unintended risks. Your mental focus, cognition, and memory show signs of improvement after the first few weeks of treatment, while feelings of depression and sudden mood swings start subsiding within three to six weeks.10 In addition to mood improvement, TRT has been found to reduce symptoms of depression and anxiety, conditions that are often exacerbated by low testosterone levels. You can stay on testosterone replacement therapy for as long as it’s benefiting your symptoms and not causing health issues. TRT has been linked to improved mood, with participants reporting better emotional wellbeing and reduced depressive symptoms. It is important for men interested in future fertility not to receive standard testostosterone replacement therapy since this can lead to low or no sperm count and infertility issues. Testosterone helps regulate other physical factors that impact mood and energy levels and protect heart health. It is also responsible for secondary sexual characteristics including muscle bulk, deep voice, and hair pattern. We source research from peer-reviewed medical journals, top government agencies, leading academic institutions, and respected advocacy groups. Testosterone provides the foundation for Hone’s testosterone replacement therapy plans, used to treat low testosterone levels and boost energy, strength, and libido. Capsules are convenient and, unlike some previous oral testosterone formulations, not thought to cause liver damage. However, they do require minor surgery each time a new dosage is due. Dose and frequency are tailored to the patient subjective symptoms and objective lab values. 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